COPPER DELIVERY TO THE CNS BY CUATSM EFFECTIVELY TREATS MOTOR NEURON DISEASE IN SODG93A MICE CO-EXPRESSING THE COPPER-CHAPERONE-FOR-SOD

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration.However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks.The Copper-Chaperone-for-SOD (CCS) protein completes the maturation of SOD by inserting copper, but paradoxic

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Explaining the role of place-making in reviving the social relations of contemporary urban neighborhoods (Case study: Selected neighborhoods of Tabriz)

Introduction: In recent decades, with the development and evolution of technology, new approaches to urban issues have been proposed.One of the important issues that Iranian cities, including the city of Tabriz, face is the social relations of contemporary neighborhoods.Since the weakness of social relations in neighborhoods can cause problems such

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Effectiveness of acute myocardial infarction interventions on selected outcomes among community dwelling-older adults: a systematic review and meta-analysis

Abstract The older adult is an influential group experiencing acute myocardial infarction, delaying treatment and causing a high mortality rate.Factors related to their delay differ from other age groups, and their specific characteristics are barriers to recognizing their symptoms and learning new information.Therefore, specific innovative methods

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